It was at the crossroads, where a large bazaar occurred on Mondays, hence the name Dushanbe-Bazar (Tajik: ).
On 10 November 1961, Stalinabad was renamed Dushanbe, the name it retains to this day.
Severe rioting occurred in February 1990, after it was rumored that the Soviet government planned to relocate tens of thousands of Armenian refugees to Tajikistan.
At that time, the town was a fortress on a steep bank on the left bank of the Varzob River with 10,000 residents.
In 1920, the last Emir of Bukhara briefly took refuge in Dyushambe after being overthrown by the Bolshevik revolution.
He fled to Afghanistan after the Red Army conquered the area the next year.