The film is set in the slums of Kibera and Loiyangalani, Kenya.
The situation affected the crew to the extent that they set up the Constant Gardener Trust in order to provide basic education around these villages. His recent performance in the play Faith Healer gained him a nomination for a 2006 Tony Award.
His sister Martha Fiennes works as a director (in her film Onegin, he acted the title role). His other sister, Sophie Fiennes is also a filmmaker.
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Fiennes also has a small role in 2010 film Nanny Mc Phee and the Big Bang, which starred Emma Thompson as the title character.
Maggie Smith also had a supporting role in the film.
In 2014, Fiennes starred in Wes Anderson's The Grand Budapest Hotel as the protagonist Monsieur Gustave H., the charismatic, philandering concierge of the titular hotel.
Born in 1962 in Suffolk, England to photographer Mark Fiennes and novelist Jennifer Lash, Fiennes is a third cousin of the adventurer Sir Ranulph Fiennes.
In 2008, Fiennes co-starred in the film In Bruges as a hitman boss.