Byrne revealed in a post-award interview that, prior to winning the Venice Film Festival award, she was surprised by her own performance and found it confronting watching the film because her acting was "too depressing".
Byrne admitted that "watching myself is confronting because I'm convinced I can't act and I want to get out, that's how insecure I am." Byrne appeared as a guest in an episode of the police drama series Murder Call.
From 2007 to 2012, she played Ellen Parsons in the cable television series Damages, which earned her two Golden Globe and two Emmy nominations.
Along with co-star Glenn Close, she appeared in all of the show's fifty-nine episodes.
She then reunited with Peter O'Toole in the BBC TV drama Casanova.