Bring It On helped push Union into the mainstream and she began gaining more exposure.
She appeared in the ABC series Flash Forward alongside John Cho and Joseph Fiennes as Zoey Andata, a role for which she was nominated for an NAACP Image Award for Outstanding Supporting Actress in a Drama Series in 2010.
In June 2011, Union defended the music video for the Rihanna single "Man Down" after it sparked controversy for Rihanna depicting a rape victim shooting and killing her attacker.
In an interview with Art Nouveau Magazine, Union complained about the lack of roles for black actresses and actors in Hollywood: "There used to be [roles] specifically written black, if you knew Denzel was doing a movie you knew his wife, girl or love interest was going to be black [but] that's not necessarily the case anymore.
You’re in that room with every amazingly talented actress of every hue, and it's a dogfight, it's hard".
She appeared in the 2005 film Neo Ned, costarring Jeremy Renner and portraying an African-American woman with delusions that she is Adolf Hitler.